Our Mission. To decode the dark genome — the 98% of human DNA that acts as the body's regulatory wiring, governing how genes turn on and off in response to the environment.
The Challenge. Science has traditionally treated DNA as a fixed blueprint. But a living organism is not fixed. It is dynamic, constantly spending energy to maintain the cellular and electrical states that keep it alive, and constantly adapting to its surroundings. The dark genome is the layer that translates external signals — diet, stress, pathogens, oxygen, temperature — into the gene activity that shapes our health. DNA sequencing is affordable. But we lack the instruments to measure how this living control layer actually processes the world.
The Impact. Understanding the gap between static DNA and a dynamic environment is a problem that spans many levels of complexity - no single method resolves it. Approach combines AI trained on public datasets for human genetic diversity with large-scale epidemiological health data, so regulatory features can be tested against things like blood pressure, blood sugar, height and weight. As the principles underlying the dark genome become discernible and measurable, they become a foundation for both clinical trials in diverse populations and ancestry-aware health.